Based on the data of 2003—2012，higher education in all provinces of our country shows the growth trend and coupled coordination with new industrialization is optimized.But the coupled coordination degree of higher education and new industrialization in China still exist significant spatial imbalance.Province with moderate and severe imbalance is the majority.The internal influencing factors analysis shows that the university scientific research level and the college degree or above in the population of elder than 6 years have the most significant influence on the new industrialization and the influence of the new industrialization is relatively balanced.Spatial measurement shows that population urbanization，transportation infrastructure and marketization have significant direct effects on the degree of coupled coordination in the spatial interaction，the transport infrastructure also has a significant spatial spillover effect，the role of industrial structure upgrade is not obvious.To promote the coupled coordination degree of higher education and new industrialization needs strengthen the internal coordination mechanism and improve the social ecological environment.